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Principles of Clinical Cancer Research

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Principles of Clinical Cancer Research

SKU# 9781620700693


  • Loren K. Mell MD
  • Phuoc T. Tran MD, PhD
  • James B. Yu MD, MHS
  • Qiang (Ed) Zhang PhD

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Principles of Clinical Cancer Research provides comprehensive coverage of the fundamentals of clinical cancer research, including the full spectrum of methodologies used in the field. For those involved in research or considering research careers, this book offers a mix of practical advice and analytical tools for effective training in theoretical principles as well as specific, usable teaching examples. The clinical oncologist or trainee will find a high-yield, practical guide to the interpretation of the oncology literature and the application of data to real-world settings. Valuable for both researchers and clinicians who wish to sharpen their skills, this book contains all the cornerstones and explanation needed to produce and recognize quality clinical science in oncology.

Written from the physician-scientist’s perspective, it lays a strong foundation in pre-clinical sciences that is highly relevant to careers in translational oncology research along with coverage of population and outcomes research and clinical trials. It brings together fundamental principles in oncology with the statistical concepts one needs to know to design and interpret studies successfully. With each chapter including perspectives of both clinicians and scientists or biostatisticians, Principles of Clinical Cancer Research provides balanced, instructive, and high-quality topic overviews and applications that are accessible and thorough for anyone in the field.

Key Features:

  • Gives real-world examples and rationales behind which research methods to use when and why
  • Includes numerous tables featuring key statistical methods and programming commands used in everyday clinical research
  • Contains illustrative practical examples and figures in each chapter to help the reader master the main concepts
  • Provides tips and pointers for structuring a career, avoiding pitfalls, and achieving success in the field of clinical cancer research
  • Access to fully downloadable ebook

Product Details 

  • Publication Date November 28, 2018
  • Page Count 456
  • Product Form Paperback / softback
  • ISBN 13 9781620700693

Table of Contents 




Chapter One: Introduction to Clinical Cancer Research

Chapter Two: Sources of Bias and Pitfalls in Clinical Cancer Research


Chapter Three: Principles of Molecular Biology

Chapter Four: The Cell Cycle, Cellular Death and Metabolism

Chapter Five: Metastasis and the Tumor Microenvironment

Chapter Six: Pre-Clinical Methods

Chapter Seven: Cancer Therapeutic Strategies and Resistance

Chapter Eight: Prognostic and Predictive Biomarkers

Chapter Nine: Working with Industry


Chapter Ten: Study Designs

Chapter Eleven: Basic Statistics for Clinical Cancer Research

Chapter Twelve: Statistical Modeling for Clinical Cancer Research

Chapter Thirteen: Cancer Epidemiology: Measuring, Exposures, Outcomes, and Risk

Chapter Fourteen: Survivorship: Effects of Cancer Treatment on Long-Term Morbidity

Chapter Fifteen: Longitudinal and Observational Studies

Chapter Sixteen: Time-to-Event Analysis

Chapter Seventeen: Machine Learning and High-Dimensional Data Analysis

Chapter Eighteen: Health Outcomes and Disparities Research

Chapter Nineteen: Cost-Effectiveness Analysis


Chapter Twenty: Introduction to Clinical Trials

Chapter Twenty-One: Early Phase Clinical Trials

Chapter Twenty-Two: Late Phase Clinical Trials

Chapter Twenty-Three: Quality of Life and Patient-Reported Outcome Analysis

Chapter Twenty-Four: Trials in Cancer Screening, Prevention, and Public Health

Chapter Twenty-Five: Imaging and Technology Trials

Chapter Twenty-Six: Adaptive and Innovative Clinical Trial Designs

Chapter Twenty-Seven: Non-Inferiority and Equivalence Trials

Chapter Twenty-Eight: Systematic Review and Meta-Analysis


Chapter Twenty-Nine: Future Directions in Clinical Cancer Research