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Advanced Physiology and Pathophysiology

Essentials for Clinical Practice

Second Edition
Editors

Linda Herrmann, PhD, RN, ACHPN, AGACNP-BC, GNP-BC, FAANP

Nancy C. Tkacs, PhD, RN

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Description

Understand Disease Mechanisms, Apply Knowledge, and Think Like a Clinician.

About This Text

This concise, well-organized text links normal physiology to the pathophysiology of common disorders and shows how mechanisms guide diagnostics and management. Learn why patients present with specific symptoms, how to interpret results, and how to translate science into clinical decisions. Includes case studies, more than 500 images, and end-of-chapter key points.

Enhance understanding and application of content with CourseConnect

CourseConnect is an interactive learning platform that provides focused lessons, practice quizzes, case studies, and progress tracking so you always know what to review next. Print copies include a CourseConnect access code.

What’s New in the Second Edition

  • Physiology of pregnancy, labor, and delivery
  • Expanded neonatal and pediatric development section
  • Cell-free DNA methylation (epigenetics) patterns in oncology
  • Expanded fluid and electrolyte balance section
  • Enhanced section on the social determinants of health
  • Introduction of the exposome concept in human disease
  • Updates on biological and psychosocial aspects of sexual development, including LGBTQ+-centered care

Why Students Love This Text

  • Clear, concise content connects physiology to pathophysiology and real-life care
  • Bridge to Clinical Practice sections help translate concepts to practical patient care.
  • Over 500 full-color images illustrate and simplify complex ideas
  • Case studies and critical-thinking questions build clinical decision-making skills
  • Chapter summaries and key points reinforce learning
  • Comprehensive lifespan coverage from pediatric to geriatric care

Get it with CourseConnect: the Smarter Way to Succeed.

Included with your print purchase. CourseConnect is an interactive learning platform that helps you learn faster, study smarter, retain more, and feel confident on exam day. Go beyond the book with tools that help you learn, apply, and assess your progress anywhere, anytime.

  • Bite-sized interactive lessons for focused, efficient study
  • Applied scenarios that connect concepts to practice
  • Quizzes and flashcards with instant feedback
  • Personal dashboard to track strengths, gaps, and progress
  • Study tools, including notes, bookmarks, and search
  • Expert-powered AI assistant offering instant, trusted guidance anytime you need it

Print books include a CourseConnect access code inside the front cover. Continuous Online Access is for the life of the product edition, plus one year.

Contents

Case Studies

Foreword by Joshua E. Faucett, DNP, MBA, FNP-BC, CNE

Acknowledgements

Contributors

Case Study Contributors

How to Use This Book

Instructor Resources

Chapter 1 The Foundational Concepts of Clinical Practice

Chapter 2 Chemical and Biochemical Foundations

Chapter 3 Molecular Biology, Genetics, and Genetic Diseases

Chapter 4 Cell Physiology and Pathophysiology

Chapter 5 Infectious Disease

Chapter 6 The Immune System and Leukocyte Function

Chapter 7 Neoplasia

Chapter 8 Blood and Clotting

Chapter 9 Circulation

Chapter 10 Heart

Chapter 11 Lungs

Chapter 12 Kidneys

Chapter 13 Gastrointestinal Tract

Chapter 14 Liver

Chapter 15 Nervous System

Chapter 16 Musculoskeletal System

Chapter 17 Endocrine System

List of Abbreviations

Index

List of Disorders

Authors

Linda L. Herrmann, PhD, RN, AGACNP-BC, GNP-BC, ACHPN, FAANP, earned her BSN, MSN, and PhD from the University of Pennsylvania School of Nursing under the mentoring of Neville E. Strumpf, PhD, RN. Dr. Herrmann's clinical and research interests are neuroscience, aging, caregiving, palliative and supportive care and end of life care, use of mixed reality platforms to enhance engagement with clinical content, and health policy related to transitions in care of older adults. She has experience teaching graduate level advanced pathophysiology and pathopharmacology in both in-person and virtual platforms. She is a nationally and internationally recognized expert in neuroscience and aging. She was a John A. Hartford predoctoral scholar, a Faculty Nurse Scholar through the Harford Faculty Scholars Program Policy Leadership Institute in Washington DC, and is an Advisor with the Hartford Institute for Geriatric Nursing and a Fellow of the American Association of Nurse Practitioners.

Nancy C. Tkacs, PhD, RN, received her BSN and MSN degrees from the University of Pennsylvania School of Nursing and her PhD in physiology with a focus in neuroscience from Loyola University of Chicago Graduate School at the Stritch School of Medicine. She completed postdoctoral training in neuroendocrinology in the laboratory of Dr. William F. (Fran) Ganong at University of California San Francisco. Dr. Tkacs conducted preclinical research on neuroendocrine responses to physiological stressors in rodent models, particularly pertaining to the diabetes complication hypoglycemia unawareness. Dr. Tkacs has been teaching pathophysiology for advanced nursing practice for over 25 years, drawing on her knowledge of organ systems physiology and pathophysiology to provide a strong basic science foundation for advanced nursing practice. As a master's-prepared nurse with a doctorate in physiology, she is able to build a bridge between physiology concepts and the pathophysiology of disease. Students learn how findings from the history and physical and diagnostic test results relate to the underlying disease process at the cell and organ level. She taught advanced pathophysiology and neuroscience courses at the University of Medicine and Dentistry of New Jersey and the New Jersey Medical School; she taught advanced pathophysiology and pathogenesis of mental health disorders courses at the University of Pennsylvania; and she directed and taught advanced pathophysiology and advanced pharmacology online courses at the University of Southern California. She also served as assistant dean for Diversity and Inclusivity at the University of Pennsylvania School of Nursing.

Instructors

Instructor eBook desk copies are available. Follow the two quick and easy steps below.

  1. Click the "REQUEST DESK COPY" button
  2. Complete the simple request form and click submit.

Upon approval, you will be granted eBook access on our Springer CONNECT platform. You will receive an email with instructions when your access is available.

All your books and their included resources will all be in one place with one log in.

    Includes the following Instructor materials:

  • LMS Common Cartridge - All Instructor Resources
  • LMS Common Cartridge Import Instructions
  • AACN Mapping Grid
  • Instructor Manuals
  • Test Bank
  • Image Bank
  • Instructor Chapter PowerPoints
  • Transition Guide: from First to Second Edition

Please visit our Resourcesfor Educators page for more information.

https://www.springerpub.com/educators

Product Details
  • Release Date: March 27, 2024
  • Paperback / softback
  • 888 Pages
  • Trim Size: 8.5in x 11in
  • Number of Illustrations: 500
  • ISBN: 9780826167552
  • eBook ISBN: 9780826167545
is focused on your learning.
Learn Smarter
Access the full eTextbook and interactive lessons that make complex concepts and clear engaging.
Apply your knowledge
Practice with real-world cases excercises and activities designed to build critical thinking and clinical skills.
Get guidance when you need it
Use Course Coach, your built-in AI tutor, to ask questions, check understanding, and stay on track, anytime, anywhere.
Grow with confidence
Follow your personal dashboard to see strengths, focus on weak spots, and master the material at your own pace.
Learn Smarter
Access the full eTextbook and interactive lessons that make complex concepts and clear engaging.
Apply your knowledge
Practice with real-world cases excercises and activities designed to build critical thinking and clinical skills.
Get guidance when you need it
Use Course Coach, your built-in AI tutor, to ask questions, check understanding, and stay on track, anytime, anywhere.
Grow with confidence
Follow your personal dashboard to see strengths, focus on weak spots, and master the material at your own pace.
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Advanced Learning for Advanced Practitioners

Get more than just an eTextbook. CourseConnect gives you the tools to study smarter, practice effectively, and succeed in your course. It's your textbook plus interactive lessons, activities, quizzes, and study tools including:

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  • Bite-sized chapters & focused lessons
  • Interactive quizzes with instant feedback
  • AI Assistant Course Coach draws from expert content to help you learn efficiently
  • Study tools like notes, bookmarks & search
  • Track your progress and know exactly where to focus
  • Not for download or use on traditional eReader devices

Study, practice, succeed. CourseConnect helps you maximize your learning with trusted content and provides the flexibility to study anytime, anywhere.

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