Multiple Sclerosis and Related Disorders

Clinical Guide to Diagnosis, Medical Management, and Rehabilitation

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Multiple Sclerosis and Related Disorders

Clinical Guide to Diagnosis, Medical Management, and Rehabilitation

Second Edition

Editors

Robert Fox, MD

Alexander D. Rae-Grant, MD

Francois Bethoux, MD

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Description

Revised and updated second edition of Multiple Sclerosis and Related Disorders: Clinical Guide to Diagnosis, Medical Management, and Rehabilitation, the only comprehensive but practical source of core information on multiple sclerosis and other demyelinating disorders. Intended as a ready reference for clinicians who provide ongoing care to MS patients, this book combines evidence-based science with experience-based guidance to present current standards and management protocols from leading MS centers.

Beginning with the scientific underpinnings of MS for clinicians, the book proceeds through diagnosis, including initial symptoms, criteria and classification, imaging, and differential diagnosis, and onto approved treatments for the various MS types and emerging therapies. Later parts of the book discuss symptom management and rehabilitation with chapters focusing on specific side effects, along with considerations for special populations, comorbidities, societal and family issues, and related autoimmune disorders that are often mistaken for MS.

Throughout, chapters include lists of Key Points both for clinicians and for patients and families, and management pearls are boxed for quick reference and clinical utility. Illustrations, tables, algorithms, assessment scales, and up-to-date MRI imaging enrich the text, making this a wide-ranging clinical reference for all members of the MS care team.

New to the Second Edition:

Includes summary recommendations from new AAN practice guidelines for use of DMTs
All chapters updated to reflect the latest literature and diagnostic criteria
Five entirely new chapters added to expand coverage of treatment, rehabilitation and symptom management, and special issues related to MS
Treatment section has been completely revised to better capture current approaches to disease modifying therapies, with separate chapters devoted to injection and oral therapies, infusion therapies, and treatments for progressive forms of MS
Related diseases section significantly expanded to include transverse myelitis, autoimmune encephalitis, and neurosarcoidosis

Contents

PART I. Basics for Clinicians

1. History of Multiple Sclerosis (T. Jock Murray)

2. Overview of Multiple Sclerosis (Alexander Rae-Grant and Robert J. Fox)

3. Pathology and Pathophysiology (Kedar R. Mahajan and Don J. Mahad)

4. Epidemiology and Natural History of Multiple Sclerosis (Marcus W. Koch)

5. Multiple Sclerosis Genetics (Bruce A. C. Cree)

PART II. Diagnosis

6. Symptoms and Signs of Multiple Sclerosis (Marisa P. McGinley and Lael A. Stone)

7. Diagnosis of Multiple Sclerosis (Thomas Shoemaker and Scott D. Newsome)

8. Magnetic Resonance Imaging In Multiple Sclerosis (Christopher J. Karakasis, Aliye O. Bricker, and Stephen E. Jones)

9. Tools and Tests for Multiple Sclerosis (Robert A. Bermel)

10. Differential Diagnosis of Multiple Sclerosis (Megan H. Hyland and Jeffrey A. Cohen)

PART III. Treatment

11. Approach to Disease Modifying Therapy (Laura E. Baldassari and Jeffrey A. Cohen)

12. Relapse Management in Multiple Sclerosis (Andrew L. Smith and Robert J. Fox)

13. Treating Relapsing Forms of Multiple Sclerosis: Injection and Oral Therapies (Le H. Hua)

14. Treating Relapsing Forms of Multiple Sclerosis: Infusion Therapies (Jenny J. Feng and Daniel Ontaneda)

15. Treating Progressive Multiple Sclerosis (Carrie M. Hersh)

16. Emerging Therapies for Relapsing Multiple Sclerosis (Peter A. Calabresi and Michael Kornberg)

PART IV. Rehabilitation and Symptom Management

17. Overview of Rehabilitation in Multiple Sclerosis (Francois Bethoux)

18. Relationship Centered Care in a Multiple Sclerosis Comprehensive Care Center (Adrienne Boissy and Claire Hara-Cleaver)

19. Fatigue in Multiple Sclerosis (Matthew Plow and Aaron Nicka)

20. Emotional Disorders in Multiple Sclerosis (Elias A. Khawam and Matthew Saco)

21. Cognitive Dysfunction in Multiple Sclerosis (Stephen M. Rao)

22. Epilepsy, Sleep Disorders, and Transient Neurological Events in Multiple Sclerosis (Burhan Z. Chaudhry and Alexander D. Rae-Grant)

23. Eye Symptoms, Signs, and Therapy in Multiple Sclerosis (Collin M. McClelland and Steven L. Galetta)

24. Bulbar and Pseudobulbar Dysfunction in Multiple Sclerosis (Devon Conway)

25. Pain Management in Multiple Sclerosis (John F. Foley, Ryan R. Metzger, Kara Menning, Cortnee Roman, and Emily N. Stuart)

26. Upper Extremity Function in Multiple Sclerosis (Christine Smith and Kathleen M. Zackowski)

27. Bladder and Bowel Dysfunction in Multiple Sclerosis (Courtenay K. Moore)

28. Sexual Dysfunction and Other Autonomic Disorders in Multiple Sclerosis (Samantha Domingo and Carolyn Fisher)

29. Spasticity Management in Multiple Sclerosis (Francois Bethoux and Mary Alissa Willis)

30. Multiple Sclerosis and Mobility (Francois Bethoux, Jacob Sosnoff, and Keith McKee)

31. General Health and Wellness in Multiple Sclerosis (Mary R. Rensel, Brandon P. Moss, and Carrie M. Hersh)

32. Complementary and Alternative Medicine: Practical Considerations (Allen C. Bowling)

PART V: Special Issues

33. Pediatric Multiple Sclerosis (Amy T. Waldman)

34. Women’s Issues (Megan E. Esch, Bridgette Jeanne Billioux, and Ellen M. Mowry)

35. Multiple Sclerosis and Associated Comorbidities (Yuval Karmon, Caila B. Vaughn, Shumita Roy, Svetlana Primma Eckert, and Bianca Weinstock-Guttman)

36. Work, Insurance, and Disability Issues in Multiple Sclerosis (Matthew H. Sutliff and Deborah M. Miller)

37. Caregiving in Multiple Sclerosis (Amy Burleson Sullivan)

Part VI. Related Diseases

38. Related Diseases (Amanda L. Piquet and John R. Corboy)

39. Acute Disseminated Encephalomyelitis (Eliza Gordon-Lipkin and Brenda Banwell)

40. Transverse Myelitis (Isabelli Strozzi and Michael Levy)

41. Autoimmune Encephalitis (Michel Toledano)

42. Neurosarcoidosis (Brandon Moss)

Authors

Robert J. Fox, MS, FAAN, MD, Medical Director; Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH

Alexander D. Rae-Grant, MD Staff, Department of Neurology, Neurological Institute, Cleveland Clinic, Director, Center for Continuing Education, Cleveland Clinic, Jane and Lee Seidman Chair for Advanced Neurological Education, Cleveland, OH.

Francois Bethoux, MD, Director of Rehabilitation Services; Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH

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