Multiple Sclerosis

Multiple Sclerosis

SKU# 9781888799620

Immunology, Pathology and Pathophysiology

Author: Robert Herndon MD


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Knowledge has been described as being like an expanding sphere with the volume of knowledge contacting a surface on the unknown. This new comprehensive review of the many fields of basic and clinical research that impact our understanding of multiple sclerosis has its basis in this premise. In doing research on MS, it is not enough to know clinical neurology or neurochemistry or neuroanatomy or pathology it is important to understand the many other areas that relate to them. This volume provides an overview of MS-related research and will benefit many investigators in the field and help to advance our efforts to cure this, thus far intractable, disease.

It is now more than 160 years since the first clinical-pathological descriptions of cases of multiple sclerosis and more than 130 years since the classic clinical description and development of diagnostic criteria by Charcot, yet MS remains an enigma. After decades of intense effort to find the cause, no cause has been clearly identified and the disease remains poorly understood. Despite the introduction of immunomodulatory therapies and immunosuppressive regimens, MS remains a devastating disease. While a great deal of progress has been made, much remains to be done. Our understanding of the disease remains limited, treatments remain inadequate, and comprehensive management all too rare.

This volume is an overview of the basic sciences as they relate to MS and will provide clinicians and investigators a better understanding of the basic aspects of the disease. While it is possible to find excellent reviews of almost any aspect of MS, few attempts have been made to bring these very different aspects together in a single source. This volume is a companion to Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation, edited by Drs. Jack S. Burks and Kenneth P. Johnson. Together, they represent an attempt to comprehensively cover the field of MS from basic research to comprehensive management and to provide a broad overview for those interested in understanding the disease better or in pursuing MS research."

Product Details 

  • Publication Date December 01, 2002
  • Page Count 300
  • Product Form Hardback
  • ISBN 13 9781888799620
  • EISBN 9781934559260

Table of Contents 

"Overview: Developments in Multiple Sclerosis Research; Morphologic Substrates of Demyelination.; Morphology of Oligodendrocytes and Myelin; Astroctes: Morphology and Function; Molecular Structure of the Myelin Membrane; Experimental Aspects of Demyelination; The Nature of Immunologic Privilege in the Central Nervous System; Experimental Autoimmune Encephalomyelitis; Tissue Culture Studies of Demyelination and Remyelination: Frederick J. Seil; Infectious Agents and Demyelination; Viral Demyelinating Diseases in Experimental Animals; Chlamydia pneumoniae Infection and its Association with Multiple Sclerosis; Cytokines, Chemokines, and Interferons; The Role of Cytokines in Multiple Sclerosis and Experimental Allergic Encephalomyelitis; Chemokines and Their Receptors in Multiple Sclerosis; Interferons in Multiple SclerosisPathology; Pathology of Demyelination; Pathology of Multiple Sclerosis as Revealed by In Vivo Magnetic Resonance - Based Approaches; Mechanisms of Repair, Adaptation, and Recovery of Function in Multiple Sclerosis; Index."

Editorial Review(s) 

"The magnetic resonance imaging chapter is a tour de force with excellent breadth and fine illustrations...a valuable resource...pleasing to a wide audience of scientists and academic physicians in the MS field." -- Archives of Neurology

"This is a well written and carefully referenced compendium of 16 excellent reviews on the basic science of multiple sclerosis. It will appeal to laboratory investigators of multiple sclerosis as well as clinicians interested in the basic science underlying multiple sclerosis."--Doody's Publishers Club

"This text is rich in scientific detail... this volume can serve as the single reference guide one would need regarding the understanding of basic mechanism associated with MS... This textbook should be required reading for the basic science researcher. It can also serve as an important allied text for the advanced basic science student in MS... the book will be an extremely useful reference to the clinician who needs to address the common questions associated with everday treatment and patient care." -- The Journal of Spinal Cord Medicine