Challenges of Biological Aging

SKU# 9780826100825

Author: Edward J. Masoro PhD

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Description 

This volume provides the non-biologist an overview of what is known about the physiological bases of aging. The author examines the many basic theories and emerging hypotheses underlying the molecular, cellular, and systemic processes involved in senescence. He addresses the normal physiological changes that characterize the aging phenotype, and also considers the role of many age-associated diseases in growing older. Masoro synthesizes a much-needed "unified theory" of biological aging to which explains how and why the body grows into the condition we call "old." This text is intended for gerontology students in training, as well as for human physiologists interested in gerontology,.

Product Details 

  • Publication Date September 05, 2000
  • Page Count 220
  • Product Form Paperback / softback
  • ISBN 13 9780826100825
  • EISBN 9780826117113

Table of Contents 

    Preface
    Acknowledgments
  1. Aging: A Biological Puzzle

  2. The Puzzle
    Mortality Risk
    Anatomical and Physiological Changes
    Age-Associated Diseases
    Concept of Biological Age
    Genetics
    Universality
  3. Demography and the Societal Challenge

  4. Population Mortality Data
    Factors Determining Population Age Structure
    Societal Impact of Changing Age Structure
    Need for Biomedical Breakthroughs
  5. Why Aging Occurs

  6. Evolutionary Biology
    History of Evolutionary Theories of Aging
    Current Evolutionary Theory of Aging
    Genetic Mechanisms in the Evolution of Aging
    Evidence Supporting the Evolutionary Theory
  7. How Aging Occurs

  8. Overview
    Theories, Hypotheses, and Concepts
    Conclusions
  9. Biological Basis of Aging: A Unifying Concept

  10. Evolutionary Theory as a Guide
    The Disposable Soma Theory of Aging
    "Private" and "Public" Proximate Mechanisms of Aging
    Unifying Concept
  11. The Human Aging Phenotype

  12. Body Structure and Composition
    Skin
    Musculoskeletal System
    Nervous System
    Cardiovascular System
    Respiratory System
    Renal and Urinary System
    Gastrointestinal System
    Endocrine and Metabolic Function
    Female Reproductive System
    Male Reproductive System
    Immune System
    Thermoregulation
  13. Possible Interventions to Retard Aging
    Dietary Restriction in Rodents
    Proposed Pharmacological Interventions
    Lifestyle and Environmental Factors
    Index